Product Information DLL4-Fc

DLL4-Fc

— Product Size —

　

10 μg
(0.1 mg/ml, 100 μl)
SP-D4F-R-010UG

　

50 μg
(0.1 mg/ml, 500 μl)
SP-D4F-R-050UG

GMP compliant

1 mg
(0.1 mg/ml, 10 ml)
SP-D4F-G-001MG

— Benefits —

AOFProduced using
a tobacco-derived host
with no animal-derived components

GMP-Compliant ManufacturingConsistent and reliable quality management

Simplified protocols without
reconstitution

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— Product Details —

NAME	Recombinant Human DLL4 (Fc Chimera active)
SOURCE	Plant Derived (Tobacco leaves)
FORMULATION	0.45M Arg-HCl / DPBS Buffer, pH 7.0
Quality	Animal Origin-Free
AA Sequence:	SGVFQLQLQE FINERGVLAS GRPCEPGCRT FFRVCLKHFQ AVVSPGPCTF GTVSTPVLGT NSFAVRDDSS GGGRNPLQLP FNFTWPGTFS LIIEAWHAPG DDLRPEALPP DALISKIAIQ GSLAVGQNWL LDEQTSTLTR LRYSYRVICS DNYYGDNCSR LCKKRNDHFG HYVCQPDGNL SCLPGWTGEY CQQPICLSGC HEQNGYCSKP AECLCRPGWQ GRLCNECIPH NGCRHGTCST PWQCTCDEGW GGLFCDQDLN YCTHHSPCKN GATCSNSGQR SYTCTCRPGY TGVDCELELS ECDSNPCRNG GSCKDQEDGY HCLCPPGYYG LHCEHSTLSC ADSPCFNGGS CRERNQGANY ACECPPNFTG SNCEKKVDRC TSNPCANGGQ CLNRGPSRMC RCRPGFTGTY CELHVSDCAR NPCAHGGTCH DLENGLMCTC PAGFSGRRCE VRTSIDACAS SPCFNRATCY TDLSTDTFVC NCPYGFVGSR CEFPVGLPAD DDDKEPKSSD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
Purity:	≥ 95% by SDS-PAGE
Endotoxin	< 1.0EU/ug
Description:	Delta-like ligand 4 (DLL4) is a Notch receptor ligand that plays a key role in regulating cell fate decisions, particularly within the hematopoietic and immune systems. DLL4-Fc is a recombinant fusion protein consisting of the extracellular domain of DLL4 fused to the Fc region of human IgG, enabling stable immobilization and efficient activation of the Notch signaling pathway in vitro. Activation of Notch signaling via DLL4-Fc has been shown to drive T-lineage commitment and differentiation, including the generation of double-positive T cells and NKT cells from hematopoietic stem and progenitor cells. DLL4-Fc is therefore widely utilized as a critical component in T cell differentiation and manufacturing platforms, particularly in iPSC-T and allogeneic CAR-T workflows.

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— Superior Induction Performance: From HPC to DP T Cells —

Efficient differentiation from HPCs into CD4⁺CD8⁺ double positive T cells(DP T cells) has been demonstrated.

ー Superior Induction Efficiency in HSPC-to-NKT Cell Differentiation ー

In a comparative study conducted by BrightPath Biotherapeutics Co., Ltd., NKT cell differentiation efficiency from HSPC using our DLL4-Fc samples was evaluated against various concentration conditions of our product as well as other commercially available DLL4-Fc product.As a result, our DLL4-Fc demonstrated higher differentiation performance.

The third-party data contained herein are provided without any warranty as to their accuracy, completeness, or freedom from infringement of intellectual property rights. We assume no liability for any damages resulting from the use of such data, and their use is strictly limited to research purposes only.

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・Product Information
DLL4-Fc ［1mg］(PDF [327KB]) DLL4-Fc ［10μg］(PDF [441KB]) DLL4-Fc ［50μg］(PDF [277KB])

・SDS (PDF [153KB])

・Brochure (PDF [1.6MB])